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Modern technologies in medicine and oncology have allowed us to make great progress in the treatment of cancer, but still the survival rate of patients is very low. Nowadays cancer is considered one of the leading causes of death worldwide, and even in developed countries mortality rates are still very high. It is evident that the development of new anticancer agents must be linked to the improvement of existing treatments, and must be addressed to tackle the main mechanisms of neoplastic growth, not only in the case of tumor cells, but also in those of tissues undergoing tumoral transformation. To this end, two main strategies can be followed: one is based on the use of drugs with high specificity (molecular), but low toxicity, and the other on drugs with broad spectrum of action, with minimal toxicity (biological), which involve, however, the normal tissue. This review aims to describe the different strategies used in the creation of nanoparticles (NPs) for cancer therapy, with special focus on the biological applications. Recent trends towards the use of NPs in medicine are summarized and their potential in cancer treatment is reviewed. Although the actual role of NPs in oncology is still to be defined, it seems evident that these nanomaterials can play a role in the development of highly effective, targeted, and harmless anticancer treatments.In 2013, Pope Francis wowed the Holy See with his encyclical “On the Love of our Neighbour”, which called for a revolution in the world of Catholic teaching to take into account how Catholics live.

In the 20 years since Francis ascended to the papacy, a lot has changed. The ordinatio sacerdotalis may be a central part of the new church Francis wants, but many other changes have come about as the Catholic Church has shifted its emphasis away from Rome and toward the world around us.

“We should be bound up in the world around us,” said Pope Francis in the Laudato siò on Care of our Common Home. “But we have not done this. We live in our own bubble.”

And nowhere is this struggle more apparent than in Catholic education.

Catholic school students are taught that they can find paradise in their Catholic

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Metallothionein (MT) is a cysteine-rich metal-binding protein, which provides cellular resistance to heavy metals. In the present study, the ability of peroxidase-catalyzed iodination to identify MT in a hepatocyte suspension was tested. A low dose of cadmium led to a strong induction of MT synthesis in isolated rat hepatocytes, and the response to cadmium was dose dependent. The induction of MT synthesis by zinc and cadmium could also be observed in three other rat liver cell lines (H4-II-E, HTC, and HTC-CAC), whereas in the Chang liver line a few MT-concentrations were found. The distribution of heavy metal-binding proteins and corresponding histochemical analysis of tissue sections revealed that peroxidase-catalyzed iodination labels a cellular form of MT in rat liver. In addition, purified liver MT of rat and human origin was shown to contain a little zinc and cadmium in absence of other heavy metals in vitro. The data suggest that hepatic cells might be involved in the regulation of zinc and cadmium concentrations through their production and distribution of MT.
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