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The release of inducible nitric oxide synthase (iNOS)-derived NO contributes to the regulation of a variety of physiological and pathophysiological processes. In this study, we evaluated for the first time the constitutive and inducible nitric oxide synthase (cNOS and iNOS) expression in primary human peritoneal mesothelial cells (HPMCs) collected from 13 different regions around the world: Australia (1 region), France (3 regions), Germany (5 regions), Iceland (1 region), Italy (4 regions), Japan (1 region), South Korea (1 region), the Netherlands (1 region), Poland (1 region), Spain (2 regions), Sweden (1 region), Turkey (1 region), and the United States (3 regions). We investigated the age of donors, their race, and sex, time between collection of the cells and RNA extraction, and their passage number. Northern and Western blot analyses showed a significant regional variation in iNOS expression. The lowest levels of iNOS expression were found in Australia, followed by Iceland, the Netherlands, and finally Sweden. In addition, an increasing correlation was found between the abundance of iNOS and the passage number of the mesothelial cells. Exposure to interleukin-1beta increased the iNOS expression in mesothelial cells. The intramesothelial NO production may play a role in the local defense against infectious and/or inflammatory agents or in pathophysiological conditions.
759 So.2d 258 (2000)
STATE of Louisiana, Appellee,
v.
Christopher W. HITCHCOCK, Appellant.
No. 34,692-KA.
Court of Appeal of Louisiana, Second Circuit.
September 27, 2000.
Writ Granted March 13, 2001.
*259 Indigent Defender Board, by Mark H

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“He has taken full responsibility for his actions. He always has,” she said of her son.

Because he had his own shooting range in his home, she was proud of his past achievements: “My son was the man that worked hard for what he got. He was a great farmer.”

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To assess the value of (18)F-fluorodeoxyglucose positron emission tomography combined with computed tomography (18F-FDG PET/CT) in detecting locoregional recurrence of oesophageal squamous cell carcinoma (OSCC) after surgery. A retrospective analysis of 28 patients (24 men, 4 women; mean age, 62.2±8.2 years) with confirmed locoregional recurrence of OSCC who underwent 18F-FDG PET/CT for detection of recurrent disease. 18F-FDG PET/CT examination was performed in the following time intervals after surgery: interval I, within 6 months of surgery; interval II, after 6 months but before 1 year; and interval III, after 1 year. 18F-FDG PET/CT images of interval I were assessed with respect to the findings obtained in interval III. The findings in intervals II and III served as the reference standard in comparison with findings in interval I. In addition to these findings, we analysed changes in the size of the tumour. The reference standard included locoregional recurrence in 24 patients and distant metastases in four patients. 18F-FDG PET/CT detected recurrent disease in 26 patients (92.8%) in interval I, three (10.7%) in interval
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